How does Actifit® work

Actifit® is a resilient, flexible, highly porous, biodegradable and biocompatible synthetic scaffold. It is a honeycomb like structure, through which blood vessels can rapidly grow. The blood transports cartilage repair cells and other nutrients that initiate the growth of new meniscus-like tissue.

Once the damaged section of the meniscus has been cut away and the meniscus resected to an area with good blood supply, the Actifit® implant is cut to size and stitched into place. Over time, the new cellular in-growth matures into new meniscus like tissue restoring the cushioning and shock absorbing function of the meniscus thus increasing the patients’ chances of a future free from pain, loss of mobility, cartilage damage and further degenerative changes.

A meniscus tear is normally repaired by the removal of the torn or damaged tissue via a partial meniscectomy. This can be effective in the short term but often it only gives temporary pain relief. In many cases the pain returns in time due to the loss of the meniscal tissue and cushioning function provided by a healthy meniscus. Over a longer period there is overwhelming evidence that degenerative changes occur, which, if left untreated, can lead to articular cartilage damage, the onset of osteoarthritis and eventually a total knee replacement.

Diagram of Actifit after arthroscopic implantation and suturing.

The pre-clinical and clinical studies show the Actifit® polymer material to be safe and effective. It has the ability to promote robust, cellular in-growth of new meniscus-like tissue. Human clinical trials have shown significant pain reduction and very promising results with regard to quality of life and a return to pre-injury activity levels at two years post surgery. See the Actifit clinical results.

To read about the polymer click here Actifit® a New Synthetic polymer PDF.

To read about how the degradation works click here Actifit® Degradation PDF.